All functions |
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APC correction. Core version, unaware of any subdivision of the dataset. |
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APC correction. Extended version, aware of subdivision of the dataset. |
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Perform FDR analysis and determine optimal Pvalue threshold |
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Determine optimal P value thresholds to have a FDR.thresh (default: 0.1) FDR |
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Derive TP and FP stats for APC based on FDR scores for a specific threshold |
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Derive TP and FP stats for APC based on FDR scores for a range of thresholds |
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Calculate ASC score |
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Add some other statistics |
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Add some other statistics |
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Compute the ME Pvalue starting from overlap statistics |
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Generic interface to calculate pairwise scores between all the pairs of alterations. Used as front-end for MI measures |
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Compute overlap statistics for the AL |
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Compute simple statistics for the AL, including accurate statistics on each sample/alteration block |
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Compute pairwise coverage |
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Compute pairwise overlap |
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Calculate simple statistics for an am |
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Binary Mutual Information. Works on single units, vectors or matrices |
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Debug version of Binary Mutual Information. Works on single units, vectors or matrices. |
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Generate random binary matrix |
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Build interaction table |
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Weighted MI measure |
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Calculate ASC score |
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Core FDR estimation |
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Interaction type aware FDR estimation |
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Get random P.values |
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Consistency enforcer for correction function for weight MI measure |
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Block aware correction function for weight MI measure |
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Correction function for weight MI measure |
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Filter AL |
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Generate random alteration landscapes |
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Generate random alteration matrix. Enables parallel calculation |
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Get sample/alteration blocks |
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Establish which threshold is the best, using the 95% of FP exclusion criterion |
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Build naive veto list by vetoing interactions of CNAs within the same chromosome |
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Assemble a table of pairwise interactions between alterations. Given N alterations, the table will contain N(N-1)/2 rows. |
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Transform a pairwise table column into tabular form, taking care of NAs |
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Convert a list of m matrices (n x n) to n lists of n vectors of m elements |
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Lung adenocarcinoma data from TCGA cohort |
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Init AL object |
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Create an Alteration Landscape Statistics (ALS) object |
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Create an Alteration Matrix Statistics (AMS) object |
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Compute P vlaue for custom score |
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Remove interactions with observed overlap strictly similar to expected overlap |
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Remove vetoed interactions (eg CNA between the same chromosome) |
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Compute custom score for the random ams |
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Compute overlap statistics for the random ams |
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SELECT analysis |
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internal SELECT routine |
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SELECT analysis on an AL with null model |